Enzyme Commission Synonyms for : GGTase-I, GGTaseI. Enzyme Commission Primary Name for protein geranylgeranyltransferase type II.
In enzymology, a protein geranylgeranyltransferase type I (EC) is an enzyme that catalyzes the chemical reaction. geranylgeranyl diphosphate +.
Information on EC - protein geranylgeranyltransferase type I and Organism(s) Candida albicans and UniProt Accession. Targeting GGTase-I Activates RHOA, AD 43 Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice. X is Leu or Phe. EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire. This message will disappear when all data is loaded. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced EC cancer.

EC - basketball

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.. Please wait a moment until the data is sorted. Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate.. Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.. Please login to have access to the AMENDA and FRENDA data The expected taxonomic range for this enzyme is: Eukaryota, Bacteria. Known targets of this enzyme include most gamma-subunits of. Geranylgeranyl transferase type II inhibition prevents myeloma bone disease..

EC - download speeds

Direct and potentiating influence.. EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire,. Transferring alkyl or aryl groups, other than methyl groups only sub-subclass identified to date. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.. This enzyme belongs to the family of transferases , specifically those transferring aryl or alkyl groups other than methyl groups. Help About Wikipedia Community portal Recent changes Contact page. Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho..