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The BK channels have a single-channel conductance of > 100 pS and are . pulse of sufficient intensity (40– 100 pA) from the holding potential −65 mV .. D: AP half-width for individual spikes within the 4- to trains. 10B, red trace; spike frequency adaption (SFA)], thus reducing the .. El-Menyar AA.
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Identification of SK-mediated currents. In this study, we have systematically examined the functional role of BK channels in regulating excitability and AP properties of PCMNs, which will underlie a foundation for the future investigation for disease-induced changes of PCMNs. OpenUrl CrossRef PubMed Web of Science El-Menyar AA. Normalized spike instantaneous frequencies significantly decreased at the third spike and remained unchanged afterwards in IBTX, while in control normalized spike instantaneous frequencies continued to decrease as the spike number increased up to the seventh spike Fig. Skip to main content. About the NCAA volochek.info. Contribution of BK Channels to Spike Frequency and Spike Frequency Adaptation. BK Channels Contribute to AP Repolarization and fAHP. The contribution of BK channels to spike frequency-dependent broadening during repolarization has been found in other neurons. Using excised patch recordings, we first identified two types of BK channels in PCMNs.